おもな業績
----- 代謝肝臓グループ

原著

  1. Kanazawa,M.,Ohtake,A.,Abe,H.,Yamamoto,S.,Satoh,Y.,Takayanagi,M.and Niimi,H.(1993)
    Molecular cloning and sequence analysis of the cDNA for human mitochondrial short-chain enoyl-CoA hydratase.
    Enzyme Protein.47,9-13.
  2. Ozaki,M.,Terada,K.,Kanazawa,M.,Fujiyama,S.,Tomita,K.and Mori,M.(1994-1995)
    Enzyme-linked immunosorbent assay of carbamoylphosphate synthetase I: plasma enzyme in rat experimental hepatitis and its clearance.
    Enzyme Protein 48,213-221.
  3. Terada,K.,Kanazawa,M.,Yano,M.,Hanson,B.,Hoogenraad,N.and Mori,M. (1997)
    Participation of the import receptor Tom20 in protein import into mammalian mitochondria: analyses in vitro and in cultured cells.
    FEBS Lett. 403,309-312.
  4. Yano,M., Kanazawa,M., Terada,K., Namchai,C., Yamaizumi,M., Hanson,B., Hoogenraad,N. and Mori,M. (1997)
    Visualization of mitochondrial protein import in cultured mammalian cells with green fluorescent protein and effects of overexpression of the human import receptor Tom20.
    J.Biol.Chem. 272,8459-8465.
  5. Kanazawa,M.,Terada,K.,Kato,S.and Mori M. (1997)
    HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria.
    J.Biochem. 239,580- 584.
  6. Kanazawa,M.,Yano,M.,Namchai,C.,Yamamoto,S.,Ohtake,A.,Takayanagi,M.,Mori,M.and Niimi,H. (1997)
    Visualization of mitochondria with green fluorescent protein in cultured fibroblasts from patients with mitochondrial diseases.
    Biochem. Biophys.Res.Commun. 239,580-584.
  7. Sugimoto,K.,Kuroki,H.,Kanazawa,M.,Kurosaki,T.,Abe,H.,Takahashi,Y.,Ishiwada,N.,Nezu,Y., Hoshioka ,A.and Toba T. (1997)
    New successful treatment with disinfectant for atopic dermatitis.
    Dermatology195,62-68.
  8. Terada,K.,Kanazawa,M.,Bukau,B.and Mori,M. (1997)
    The human DnaJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding.
    J.Cell Biol.139,1089-1095.
  9. Kogo,T.,Satoh,Y.,Kanazawa,M.,Yamamoto,S.,Takayanagi,M.,Ohtake,A.,Mori,M.and Niimi H.(1998)
    Expression analysis of two mutant human ornithine transcarbamylases in COS-7 cells.
    J.Hum.Genet.43,54-58.
  10. Yano,M.,Kanazawa,M.,Terada,K.,Takeya,M.,Hoogenraad,N.and Mori M. (1998)
    Functional analysis of human mitochondrial receptor Tom20 for protein import.
    J.Biol.Chem.273,26844-26851.
  11. Ogawa,A.,Yamamoto,S.,Takayanagi,M.,Kogo,T.,Kanazawa,M.and Kohno Y. (1999)
    Identification of three novel mutations in the MNK gene in three unrelated Japanese patients with classical Menkes disease.
    J.Hum.Genet. 44,206-209.
  12. Ogawa,A.,Yamamoto,S., Takayanagi,M.,Kogo,T.,Kanazawa,M.and Kohno,Y. (1999)
    An Ile/Val polymorphism at codon 1464 of the ATP7A gene.
    J.Hum.Genet.44,423-424.
  13. Shiojiri,N.,Sano,M.,Inujima,S.,Nitou,M.,Kanazawa,M.and Mori,M. (2000)
    Quantitative analysis of cell allocation during liver development, using the spf(ash)-heterozygous female mouse.
    Am.J.Pathol. 156,65-75.
  14. Ogawa,A.,Yamamoto,S.,Kanazawa,M.,Ogawa,E.,Takayanagi,M.,Hasegawa,S,and Kohno,Y. (2000)
    Novel mutation of L718X in the ATP7A gene in a Japanese patient with classical Menkes disease, and four novel polymorphisms in the Japanese population.
    J.Hum.Genet. 45,315-317.
  15. Jibiki,T.,Terai,M.,Shima,M.,Ogawa,A., Hamada,H., Kanazawa,M.,Yamamoto,S.,Oana,S.and Kohno Y.(2001)
    Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease.
    Arthritis Rheum.44,2211-2212.
  16. Ogawa,E.,Ogawa.,A., Kanazawa,M.,Yamamoto,S.,Terai ,M.,Takayanagi,M.and Kohno,Y. (2002)
    Expression analysis of two mutations in carnitine palmitoyltransferase IA deficiency.
    J Hum Genet, 47,342-347.
  17. Takanashi J, Kurihara A, Tomita M, Kanazawa,M., Yamamoto S, Morita F, Ikehira H, Tanada S, Kohno Y. (2002)
    Distinctly abnormal brain metabolism in late-onset ornithine transcarbamylase deficiency.
    Neurology. 59(2),210-214.
  18. Kurihara A, Takanashi J, Tomita M, Kobayashi K, Ogawa A, Kanazawa,M., Yamamoto S, Kohno Y. (2003)
    Magnetic resonance imaging in late-onset ornithine transcarbamylase deficiency.
    Brain Dev. 25(1),40-44.
  19. Kobayashi S, Ochiai T, Hori S, Suzuki T, Shimizu T, Gunji Y, Shimada H, Kanazawa,M., Ogawa A, Kohno Y, Hirasawa H, Oda S, Tanaka K. (2003)
    Complete recovery from fulminant hepatic failure with severe coma by living donor liver transplantation.
    Hepatogastroenterology.50, 515-518.
  20. Kojima K, Kure S, Kamada F, Hao K, Ichinohe A, Sato K, Aoki Y, Yoichi S, Kubota M, Horikawa R, Utsumi A, Miura M, Ogawa S, Kanazawa,M., Kohno Y, Inokuchi M, Hasegawa T, Narisawa K, Matsubara Y.(2003)
    Genetic testing of glycogen storage disease type Ib in Japan: five novel G6PT1 mutations and a rapid detection method for a prevalent mutation W118R.
    Mol Genet Metab. 81,343-346.
  21. Yuan RH, Ogawa A, Ogawa E, Neufeld D, Zhu L, Shafritz DA. (2003)
    P27kip1 inactivation provides a proliferation advantage to transplanted hepatocytes in DPPIV/Rag2 double knockout mice after repeated host liver injury.
    Cell Transplant. 12:907-19
  22. Satoko Ohtsuka, Katsuro Iwase, Masaki Kato, Naohiko Seki, Atsuko Shimizu-Yabe, Osamu Miyauchi, Eiko Sakao, Masaki Kanazawa, Shigenori Yamamoto, Yoichi Kohno and Masaki Takiguchi(2004)
    An mRNA amplification procedure with directional cDNA cloning and strand-specific cRNA synthesis for comprehensive gene expression analysis.
    Genomics. 84,715-729.
  23. Nierhoff D, Ogawa A, Oertel M, Chen YQ, Shafritz DA. (2005)
    Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity.
    Hepatology 42:130-9
  24. Ju W, Ogawa A, Heyer J, Nierhoff D, Yu L, Kucherlapati R, Shafritz DA, Bottinger EP. (2006)
    Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.
    Mol Cell Biol. 26: 654-67

症例報告

  1. Ogawa,A.,Yamamoto,S.,Kanazawa,M.,Takayanagi,M.,Hasegawa,S.and Kohno Y.(2000)
    Identification of two novel mutations of the carnitine/acylcarnitine translocase (CACT) gene in a patient with CACT deficiency.
    J.Hum.Genet. 45,52-55.
  2. 山本重則, 阿部博紀, 金澤正樹，佐藤好範，花城恵美子，向後利昭，柿沼宏明，大竹明，高柳正樹，長谷川修司，新美仁男 (1995)
    カルニチン療法を長期継続している,乳児期発症のビタミンB12不応型メチルマロン酸尿症の一例　これまでの10年間の経過と治療を振り返ってみて.
    特殊ミルク情報 31,17-20.
  3. 向後利昭, 金澤正樹, 山本重則，新美仁男，阿部博樹，大竹明，高柳正樹 (1996)
    5-ヒドロキシトリプトファン投与中止後も良好な経過をたどっている6-ピルボイルテトラヒドロプテリン合成酵素欠損症の1例.
    特殊ミルク情報 32,9-13.
  4. 小林進, 落合武徳, 堀誠司, 鈴木孝雄, 清水孝徳, 軍司祥雄, 剣持敬, 島田英昭, 岡住慎一, 林秀樹, 西郷健一, 高山亘, 岩崎好太郎, 牧野治文, 松井芳文, 丸山通弘, 三浦文彦, 伊藤泰平, 近藤悟, 大平学, 吉永有信, 北林宏之, 小林豊, 間宮俊太, 金澤正樹, 小川真司, 河野陽一, 平野剛, 中西加寿也, 志賀英敏, 織田成人, 平澤博之, 一瀬正治, 大塚恭寛, 吉田英生, 大沼直躬, 横須賀収, 松谷正一, 今関文夫, 丸山紀史,税所宏光, 根橋紫乃, 篠塚典弘, 佐藤二郎, 西野卓, 野村文夫, 加藤佳瑞紀, 尾崎大介, 石倉浩, 中野喜正, 守田文範, 梁川範幸, 北原宏, 中村裕義, 北田光一, 古山信明, 田中紘一 (2001)
    生体部分肝移植で救命しえた肝性昏睡V度の亜急性型劇症肝炎の1例.
    千葉医学雑誌77,359-366.
  5. 寺岡通雄, 和田智顕, 小倉和郎, 安原伸吾, 喜多村哲朗, 村上暢子, 伊藤滋, 金澤正樹, 重松陽介 (2004)
    長期抗生剤投与により低カルニチン血症を来たしたと考えられた1例.
    日本小児科学会雑誌108,1056

症例報告

  1. 山本重則,　阿部博樹,　金澤正樹,　小川真司,　向後利昭,　花城恵美子,　佐藤好範,　高柳正樹,　柿沼宏明,　大竹明,　新美仁男（1995）
    ミトコンドリア脂肪酸酸化異常症　−その臨床像の特徴と診断の進め方−.
    小児科36,1293−1299.
  2. 金澤正樹, 森正敬　(1995)
    分子シャペロンと細胞内蛋白質輸送.
    実験医学13,1413-1418.
  3. 金澤正樹, 森正敬　(1998)
    タンパク質のミトコンドリア輸送と疾患.
    臨床化学　27,171-184.
  4. 金澤正樹, 森正敬　(2002)
    尿素サイクルと関連酵素.
    日本臨床.